Abstract: The proper choice of raw materials and manufacturing parameters for Cross Laminated Timber is essential to promote the proper bonding of the lamellas, aiming at their application in construction. However, few Brazilian species are currently used in the production of Cross Laminated Timber. The aim of this work was to characterize the bonding quality of four Brazilian reforestation species (Pinus elliottii (pino ellioti), Eucalyptus grandis (eucalipto), Toona ciliata (toona) and Acrocarpus fraxinifolius (lazcar)) in the manufacture of Cross Laminated Timber with two-component polyurethane adhesive and five different pressure levels (from 0,1 MPa to 1,3 MPa). Bonding quality was evaluated through delamination and glue line shear tests based on the European standard. Delamination was affected by the wood species, and the best adhesion occurred for the Cross Laminated Timber manufactured with Pinus elliottii (pino ellioti) and Acrocarpus fraxinifolius (lazcar) at the bonding pressure of 0,7 MPa. Cross Laminated Timber bonding pressure did not affect the percentage of wood in the shear test fractured surface, whereas higher density Cross Laminated Timber showed higher percentages.

Cancer is one of the major causes of death worldwide, and breast cancer is the most prevalent and deadly type among women. Despite the side effects and the phenomena of chemoresistance associated with the drugs involved, chemotherapy remains the main therapeutic strategy to combat and control breast cancer. Therefore, several new classes of compounds against breast cancer have been explored, in an effort to identify new drug candidates with alternative mechanisms of action. The principal results of such exploration, focusing on caged xanthones, thiosemicarbazones and photosensitizers, are presented in this review, along with the main aspects of the drug discovery process against breast cancer. More specifically, the design, structure-activity relationship investigations and anti-breast cancer properties of these three classes are described and discussed in this work. worldwide women involved Therefore explored action exploration xanthones photosensitizers review specifically design structureactivity structure activity antibreast anti work

Abstract Anterior dislocations represent about 96% of total shoulder dislocations, with recurrence/instability being more common in young patients. Injury of other shoulder structures is frequent, namely bony Bankart lesion. However, the association with coracoid apophysis fracture is very rare. The present article describes the clinical case of a 67-year-old man who presented to the emergency department with complaints of persistent omalgia, with acute episodes, beginning after a fall from his own height. The patient also presented history of shoulder trauma 3 months earlier, which was evaluated at another hospital. Shoulder anterior dislocation was observed radiographically, and the computed tomography (CT) confirmed bone erosion of the anteroinferior part of the glenoid (bone loss of about 50% of the anteroposterior diameter in the lower region of the glenoid), with almost complete resorption of the bony Bankart lesion (apparent in later analysis of the radiography of the initial traumatic episode). Connectedly, a transverse fracture of the coracoid apophysis (type II in the Ogawa classification) was diagnosed. The patient was submitted to surgical treatment, with anterior bone stop confection using the remnant of the fractured fragment of the coracoid supplemented by tricortical autologous iliac graft, fixed with cannulated screws (according to the Bristow-Latarjet and Eden-Hybinett techniques). In the postoperative follow-up, a good functional result was observed, with no new episodes of dislocation and no significant pain complaints. A rare association of shoulder lesions is described, and the challenge of their treatment is highlighted, given the late diagnosis, as in the case presented.

Resumo As luxações anteriores representam cerca de 96% do total de luxações do ombro, sendo a recidiva/instabilidade mais comum em pacientes jovens. A lesão de outras estruturas do ombro é frequente, nomeadamente a lesão óssea de Bankart. Contudo, a associação com a fratura da apófise coracoide é muito rara. Este artigo descreve o caso clínico de um homem de 67 anos que recorreu ao serviço de urgência com queixas de omalgia persistente, com episódios de agudização, iniciados após queda da própria altura. O paciente apresentava ainda histórico de trauma do ombro 3 meses antes, avaliado em outro hospital. A luxação anterior do ombro foi constatada radiograficamente, e a tomografia computorizada (TC) do ombro confirmou erosão óssea da vertente anteroinferior da glenoide (perda óssea de cerca de 50% do diâmetro anteroposterior na região inferior da glenoide), com reabsorção quase completa de lesão óssea de Bankart (aparente em análise a posteriori da radiografia do episódio traumático inicial). Associadamente, foi diagnosticada uma fratura transversa da apófise coracoide (tipo II da classificação de Ogawa). O paciente foi submetido ao tratamento cirúrgico, com confecção do batente ósseo anterior utilizando remanescente do fragmento fraturado do coracoide suplementado por enxerto autólogo tricortical do ilíaco, fixados com parafusos canulados (de acordo com as técnicas de Bristow-Latarjet e Eden-Hybinett). No seguimento pós-operatório, foi observado um bom resultado funcional, sem novos episódios de luxação e sem queixas álgicas significativas. Descreve-se uma associação rara de lesões do ombro, e salienta-se o desafio do tratamento das mesmas dado o seu diagnóstico tardio, como no caso apresentado.

RESUMO Estresses abióticos associados causam efeitos e respostas diferentes da exposição a uma única fonte de estresse. Objetivou-se avaliar o efeito do estresse combinado de temperatura supraótima e déficit hídrico no processo germinativo de lotes de sementes de trigo com diferentes níveis de vigor. Sementes de trigo IPR Catuara de quatro lotes foram submetidas a germinação nos potenciais hídricos 0,000, - 0,075, - 0,223 e - 0,444 MPa, associados às temperaturas 20, 24, 28 e 32 ºC, totalizando 16 combinações de estresse. O delineamento experimental foi inteiramente casualizado, com quatro repetições, em esquema fatorial: quatro lotes x 16 combinações de estresse, e comparação de médias por Scott-Knott 5%. Avaliaram-se a germinação das plântulas normais aos quatro e oito dias, o conteúdo de proteína total e a atividade da catalase e ascorbato peroxidase (APX) na parte aérea e radicular das plântulas. As análises de componentes principais e de agrupamento hierárquico foram aplicadas à matriz original formada pelas 16 combinações, para a média dos quatro lotes. Sementes de trigo de maior vigor são mais tolerantes a combinação dos estresses hídrico e térmico. Não há prejuízo ao processo germinativo de trigo nas combinações sob temperaturas supraótimas até 28 °C e redução dos potenciais hídricos até -0,223 MPa. Independente da temperatura, o potencial hídrico -0,444 MPa diminui a porcentagem e a velocidade da germinação. A atividade da APX aumenta em condições de estresses hídrico e térmico atuando como defesa ao estresse oxidativo na germinação de trigo.

ABSTRACT Combined abiotic stresses have different effects and responses than exposure to a single source of stress. The objective of this study was to evaluate the effect of the combined stress of supra-optimal temperatures and water deficit on the germination of wheat seeds with different levels of vigor. Wheat seeds from four different lots of the IPR Catuara cultivar were germinated at water potentials of 0.000, -0.075, -0.223, and -0.444 MPa, associated with temperatures of 20 °C, 24 °C, 28 °C, and 32 °C, totaling 16 stress combinations. The experimental design was completely randomized in a factorial scheme with four replications (four seed lots × 16 stress combinations), and means were compared using Scott-Knott 5%. We evaluated the germination of normal seedlings at 4 and 8 d, the activity of catalase and ascorbate peroxidase (APX), and the protein content of the aerial and root parts of wheat seedlings. Principal components analysis and hierarchical clustering were applied to the original matrix formed by the 16 combinations for the average of the four lots. Wheat seeds with higher vigor were more tolerant to combined water and thermal stress. Temperatures up to 28 °C and reduction of water potentials down to -0.223 MPa did not prejudice the germination process of wheat seeds. Regardless of temperature, a water potential of -0.444 MPa decreased the percentage and rate of germination. APX activity increased under water stress and supra-optimal temperatures, acting as a defense mechanism against oxidative stress.

Abstract During the academic life, university students are constantly subjected to stress situations, especially those in the health area due to an extensive curriculum, contact with critically ill patients, among others. This study aimed to analyze the prevalence of Burnout Syndrome and the associated factors among university students in health at a private institution in northern Minas Gerais. Quantitative study with cross-sectional and analytical cohort. For data collection we used a structured questionnaire related to sociodemographic aspects and another validated instrument MBI-SS - Maslach Burnout Inventory Student Survey to assess stress. Descriptive analysis (mean, standard deviation, percentages and frequencies) and association were performed, considering a significance level of 5%, using the chi-square test. Two hundred and twenty-two academics participated in this study, in which 20.5% had burnout, presenting as associated factors: age (0.044), type of course (0.005), moderate level of Emotional Exhaustion (50.7%) and high Depersonalization (76.4%) and Professional Achievement (70%). It was identified that a significant portion of the population studied had Burnout Syndrome, especially those over 21 years old enrolled in Pharmacy, Psychology and Nursing courses. And factors such as depersonalization, professional fulfillment, professional exhaustion were considerably interconnected.

Resumo Durante a vida acadêmica os estudantes universitários são constantemente submetidos a situações de estresse, principalmente os da área da saúde devido a uma grade curricular extensa, contato com pacientes graves, dentre outros. O objetivo deste estudo foi analisar a prevalência da Síndrome de Burnout e os fatores associados entre universitários dos cursos da área da saúde em uma instituição privada no Norte de Minas Gerais. Estudo quantitativo, com coorte transversal e analítico. Para a coleta de dados foi utilizado um questionário estruturado relacionado aos aspectos sociodemograficos e outro instrumento validado MBI-SS - Maslach Burnout Inventory Student Survey para avaliar o estresse. Realizou-se a análise descritiva (média, desvio padrão, percentagens e frequências) e associação, considerando nível significância de 5%, por meio do teste qui-quadrado. Participaram deste estudo 292 acadêmicos, em que 20,5% apresentaram Burnout, apresentando como fatores associados: idade (0,044), tipo de curso (0,005), nível moderado de Exaustão Emocional (50,7%) e alto de Despersonalização (76,4%) e Realização Profissional (70%). Identificou-se que uma parcela significativa da população estudada apresentava a Síndrome de Burnout, principalmente àqueles com mais de 21 anos de idade matriculados nos cursos de Farmácia, Psicologia e Enfermagem. E fatores como despersonalização, realização profissional, exaustão profissionais estavam interligados de modo consideráveis.

Resumo: A ABP vem sendo utilizada como método de aprendizagem no mundo todo, porém, no ensino da graduação em enfermagem ainda é pouco utilizada. Considera-se relevante a realização de estudos a partir das experiências de estudantes e egressos de um curso que se utiliza da mesma. Objetivo: Compreender a percepção de estudantes e egressos sobre a utilização da ABP no curso de graduação em enfermagem. Método: Trata-se de um estudo qualitativo pautado na modalidade compreensiva e interpretativa, fundamentada nos pressupostos da Hermenêutica-Dialética. Foi realizado a partir de quatro grupos focais com 17 estudantes e 16 egressos de uma instituição de ensino superior do interior do estado de São Paulo, que se utiliza da ABP na formação dos enfermeiros de forma remota. O convite para participar do estudo foi feito via e-mail, Whatsapp e Facebook, ocasião em que foram explicados os objetivos do estudo, verificando-se o interesse em participar. Resultados: A análise dos dados levou à elaboração de cinco categorias temáticas, sendo elas: sofrimento para se apropriar da lógica da aprendizagem ativa; aquisição de autonomia para busca contínua do conhecimento; estímulo ao raciocínio clínico; melhora das relações interpessoais e comunicação; e, por fim, articulação teórico-prática. Conclusões: Ao utilizar a APB, há uma aproximação com as orientações dadas pelas diretrizes curriculares para a formação do enfermeiro, promovendo a aquisição de autonomia para a busca contínua do conhecimento, a capacidade de comunicação e de relações interpessoais e o desenvolvimento do raciocínio clínico e do pensamento crítico, levando a uma prática contextualizada e ampliada. Ressalta-se, ainda, a potencialidade do estudo para a pesquisa qualitativa por utilizar-se de grupos focais online, superando, assim, os desafios da pesquisa qualitativa em ambientes virtuais.

Abstract: ABP has been used as a learning method all over the world, however, in undergraduate nursing education it is still little used. It is considered relevant to carry out studies based on students and graduates’ experiences of a degree course that use this method. Main Goal: To understand the perception of students and graduates about the use of PBL in the undergraduate nursing course. Method: This is a qualitative study guided by the comprehensive and interpretive modality, based on dialectical hermeneutics assumptions. The research was conducted from four focus groups with 17 students and 16 graduates from a higher education institution in the interior of the state of São Paulo that uses PBL remotely in nurses’ training. The invitation to participate in the study was made via email, WhatsApp and Facebook, when the analysis’ goals were explained and the interest in participating was verified. Results: Data analysis led to the elaboration of five thematic categories, namely: suffering to appropriate the logic of active learning; acquisition of autonomy for the continuous search for knowledge; stimulation of clinical reasoning; improved interpersonal relationships and communication; and finally, theoretical-practical articulation. Conclusions: When using the PBL, there is an approximation with the curricular guidelines for the nurses’ training, promoting the acquisition of autonomy for the continuous search for knowledge, the ability to communicate and interpersonal relationships, the development of clinical reasoning and critical thinking, leading to a contextualized and expanded practice. Furthermore, we emphasize the potential of the study for qualitative research, using online focus groups, thus overcoming the challenges of qualitative research in virtual environments.

ABSTRACT Objectives: To evaluate the effect of sitagliptin treatment in early type 2 diabetes mellitus (T2DM) and the impact of different macronutrient compositions on hormones and substrates during meal tolerance tests (MTT). Materials and methods: Half of the drug-naive patients with T2DM were randomly assigned for treatment with 100 mg of sitagliptin, q.d., or placebo for 4 weeks and then submitted to 3 consecutive MTT intercalated every 48 h. The MTTs differed in terms of macronutrient composition, with 70% of total energy from carbohydrates, proteins, or lipids. After 4 weeks of washout, a crossover treatment design was repeated. Both patients and researchers were blinded, and a repeated-measures ANOVA was employed for statistical analysis. Results: Sitagliptin treatment reduced but did not normalize fasting and post-meal glucose values in the three MTTs, with lowered area-under-glucose-curve values varying from 7% to 15%. The sitagliptin treatment also improved the insulinogenic index (+86%) and the insulin/glucose (+25%), glucagon-like peptide-1/glucose (+46%) incremental area under the curves. Patients with early T2DM maintained the lowest glucose excursion after a protein- or lipid-rich meal without any major change in insulin, C-peptide, glucagon, or NEFA levels. Conclusion: We conclude that sitagliptin treatment is tolerable and contributes to better control of glucose homeostasis in early T2DM, irrespective of macronutrient composition. The blood glucose excursion during meal ingestion is minimal in protein- or fat-rich meals, which can be a positive ally for the management of T2DM. Clinical trial no: NCT00881543

Abstract: Aiming to provide greater visibility for the wood species Acrocarpus fraxinifolius, the present study sought to analyze the influence of heat treatment on an industrial scale applied to wood species, also popularly known as Indian cedar. The heat treatment was carried out in an autoclave, with temperature and pressure control, and with saturated steam injection, for temperatures 155 ºC, 165 ºC, 175 ºC, and 185 ºC. Physical, chemical, and mechanical tests were carried out for the analyzed wood. The content of holocellulose and total lignin decreased, while the content of extractives showed a substantial increase. The density increased after the heat treatment, however the treated wood showed cracks, and these cracks influenced the significant loss of the values of the mechanical properties of compression, tension, and flexion. The shear showed strength gain for the temperature of 155 ºC, and the wood treated at 165 ºC was equivalent to untreated wood. The woods submitted to temperatures of 175 ºC and 185 ºC presented strength losses. The heat treatment in question contributes to increase the visibility, use and market value of wood.

RESUMO Objetivos: compreender os determinantes envolvidos no sofrimento mental de crianças escolares na fronteira franco-brasileira. Métodos: estudo qualitativo realizado com crianças de 6 a 12 anos, de quatro escolas estaduais do município de Oiapoque, localizadas na fronteira franco-brasileira. Os dados foram obtidos por meio de entrevistas, analisados pelo software IRAMUTEQ e interpretados à luz do modelo de determinantes sociais da saúde de Dahlgren e Whitehead. Resultados: os dados apontam que o sofrimento mental vivenciado pelas crianças, especialmente caracterizado por sintomas ansiosos, como medo de ficar gordo e preocupação, eram permeados por situações sociais pelas quais as crianças passavam no dia a dia, como abandono familiar, violência doméstica e bullying. Considerações Finais: os determinantes sociais podem ser preditores do sofrimento mental em crianças, sobretudo em ambientes de extrema vulnerabilidade, como o de fronteira, em que permeiam situações relacionadas a dificuldades financeiras, violência doméstica e ausência de parentalidade.

ABSTRACT Objectives: to understand the determinants involved in the mental suffering of schoolchildren on the French-Brazilian border. Methods: a qualitative study was conducted with children from 6 to 12 years of age from four State schools in the municipality of Oiapoque, located on the French-Brazilian border. The data were obtained through interviews, analyzed by the IRAMUTEQ software, and interpreted in the light of the Dahlgren and Whitehead’s social determinants of health model. Results: data indicate that the mental suffering experienced by children, especially characterized by anxious symptoms, such as concern of becoming fat and worries, were permeated by social situations that children went through daily, such as family abandonment, domestic violence, and bullying. Final Considerations: social determinants can be predictors of mental suffering in children, especially in environments of extreme vulnerability, such as the border, in a context of financial difficulties, domestic violence, and absence of parenting.

RESUMEN Objetivos: comprender los determinantes involucrados en el sufrimiento mental de los escolares de la frontera franco-brasileña. Métodos: estudio cualitativo realizado con niños de 6 a 12 años de cuatro escuelas públicas del municipio de Oiapoque, ubicadas en la frontera franco-brasileña. Los datos fueron obtenidos a través de entrevistas, analizados por el software IRAMUTEQ e interpretados a la luz del modelo de determinantes sociales de la salud de Dahlgren y Whitehead. Resultados: los datos muestran que el sufrimiento mental experimentado por los niños, especialmente caracterizado por síntomas ansiosos, como el miedo a engordar y la preocupación, estuvo permeado por situaciones sociales por las que atravesaron los niños en su vida diaria, como el abandono familiar, la violencia doméstica y intimidación. Consideraciones Finales: los determinantes sociales pueden ser predictores de sufrimiento mental en los niños, especialmente en entornos de extrema vulnerabilidad, como el de frontera, en un contexto de dificultades económicas, violencia doméstica y ausencia de paternidad.

Abstract: Indian cedar (Acrocarpus fraxinifolius) is a wood species that occurs naturally in India, Myanmar (Burma) and Bangladesh, and has a high commercial value, with characteristics like mahogany and native cedars. The planting of Indian cedar has been undertaken in Brazil, but there is little information available regarding the characterization of the species. Therefore, considering its timber potential and its possibility of development in the country, the present work aimed to evaluate the physical, chemical, and mechanical properties of 9-year-old Indian cedar wood, planted in the southern region of Brazil. A low specific mass (502 kg/m³), low average dimensional stability (anisotropy coefficient of 2,09 %) was observed, in addition to the low content of extractives (1,94 %). From the mechanical characterization, an average value for the elastic modulus of 8963 MPa was obtained, and for the compressive strength parallel to the grain the average and characteristic values were 32,14 MPa and 21,46 MPa, respectively. This indicates that this wood belongs to resistance class C20 (dicotyledons). The results obtained classify the wood for use in light, external, or internal civil construction.

Resumo Este artigo busca contar as narrativas de jovens que nasceram com HIV apresentadas em rodas de conversa de um Grupo de Trabalho sobre Transmissão Vertical do HIV e Juventudes. Os temas abordados dizem respeito à empregabilidade e benefícios sociais, bem como analisam a perda de aposentadorias por Pessoas Vivendo com HIV/aids (PVHA) no período de 2016 a 2019. O método utilizado para esta pesquisa qualitativa é a autoetnografia de uma ativista travesti negra e intersexo, além da análise documental de atas, notícias, memórias de reuniões, anotações pessoais e legislações, tendo como escolha conceitual de análise a interseccionalidade.

Abstract This article presents the narratives of young people born with HIV told in chatting circles of a Working Group on Vertical Transmission of HIV and Youth. The themes relate to employability and social benefits, as well as the loss of retirement pensions by people living with HIV/AIDS (PLHA) from 2016 to 2019. Based on the concept of intersectionality, this qualitative research consists of the autoethnography of a Black intersex travesti activist and of a document analysis of minutes, news, meeting memories, personal notes, and legislations.

Abstract The Brazilian Code ABNT NBR 7190 (1997) is currently under review process and one of the proposals is the change and add of some test procedures. Several specimen geometric configurations and test conditions have been evaluated by the study committee CE-02:126.10. The aim of this paper was the analysis of the tensile strength perpendicular to the grain through the current Brazilian Code and from an adaptation of ISO 13910 (2005). Pine and Indian Cedar were used and simplified relationships were proposed. Numerical simulations were performed to identify the stress distributions in the specimens. The results obtained by ISO 13910 (2005) did not differ statistically for the two species. Brazilian standard method cedar had a higher strength value than pine. The simplified ratios obtained ranged between 0,017 and 0,123. The numerical simulations of ISO 13910 (2005) specimens showed predominant failure by tension in the lower fiber due to stress concentration.

RESUMO Objetivo Avaliar o ângulo de fase como método de triagem para sarcopenia. Métodos Estudo transversal realizado com 169 idosas ativas de comunidade. O ângulo de fase foi obtido por bioimpedância elétrica tetrapolar e a sarcopenia foi diagnosticada a partir da massa muscular esquelética, força muscular e performance física utilizando bioimpedância elétrica, dinamometria manual e o teste de velocidade de marcha, respectivamente. A curva Receiver Operating Characteristic foi construída para avaliar o ângulo de fase como preditor de sarcopenia. Resultados A prevalência de sarcopenia foi de 12,4%. A mediana do ângulo de fase foi de 5,30°; idosas com sarcopenia apresentaram valores menores do ângulo de fase em relação às não sarcopênicas (p=0,024). O ponto de corte do ângulo de fase para identificar sarcopenia foi ? 5,15°, com área sob a curva de 0,685, sensibilidade de 81,0%, especificidade de 60,8% e acurácia de 63,31%. Observou-se que idosas com ângulo de fase reduzido apresentaram maior chance de terem massa muscular reduzida e sarcopenia. Conclusão O ângulo de fase se mostrou útil para triagem de idosas com sarcopenia.

ABSTRACT Objective We investigated the utility of the phase angle as a screening tool for sarcopenia. Methods We performed a cross-sectional study that included 169 active community-dwelling elderly women. The phase angle was determined using tetrapolar bioelectrical impedance, and sarcopenia was diagnosed based on skeletal muscle mass, muscle strength, and physical performance using bioelectrical impedance analysis, a handheld dynamometer, and the gait speed test, respectively. Receiver operating characteristic curve analysis was performed to investigate the role of the phase angle as a predictor of sarcopenia. Results The prevalence of sarcopenia was 12.4%. The median phase angle was 5.30°; elderly women with sarcopenia had lower phase angles than those without sarcopenia (p=0.006). The phase angle cutoff for the detection of sarcopenia was ?5.15°, with an area under the curve of 0.685, sensitivity 81.0%, specificity 60.8%, and accuracy 63.31%. Elderly women with a low phase angle show a high risk of presenting with reduced muscle mass. Conclusions The phase angle was shown to be a useful screening tool in elderly women with sarcopenia.

Resumo Este artigo busca contar as narrativas de jovens que nasceram com HIV apresentadas em rodas de conversa de um Grupo de Trabalho sobre Transmissão Vertical do HIV e Juventudes. Os temas abordados dizem respeito à empregabilidade e benefícios sociais, bem como analisam a perda de aposentadorias por Pessoas Vivendo com HIV/aids (PVHA) no período de 2016 a 2019. O método utilizado para esta pesquisa qualitativa é a autoetnografia de uma ativista travesti negra e intersexo, além da análise documental de atas, notícias, memórias de reuniões, anotações pessoais e legislações, tendo como escolha conceitual de análise a interseccionalidade.

Abstract This article presents the narratives of young people born with HIV told in chatting circles of a Working Group on Vertical Transmission of HIV and Youth. The themes relate to employability and social benefits, as well as the loss of retirement pensions by people living with HIV/AIDS (PLHA) from 2016 to 2019. Based on the concept of intersectionality, this qualitative research consists of the autoethnography of a Black intersex travesti activist and of a document analysis of minutes, news, meeting memories, personal notes, and legislations.